Anatomical and refractive outcomes in patients with treated retinopathy of prematurity

Abstract

Abstract Objective To describe the anatomical and refractive outcomes after treatment with intravitreal bevacizumab or laser in a patient cohort with retinopathy of prematurity (ROP). Methods A multicenter, prospective, and observational study was performed on patients with ROP treated at Hospital Roberto del Rio. Those patients with less than 6 months of follow-up were excluded. Cases with posterior zone II , zone I ROP, and aggressive posterior ROP (AP-ROP) were treated with intravitreal bevacizumab. All other patients were treated with laser. Follow-up was performed every 3 months, and included fondo evaluation, refraction, and Teller tests. Results The treated group included 144 eyes of 72 patients, of whom 49 were treated with laser and 23 with intravitreal bevacizumab. One (1.4%) patient from the laser group progressed to stage 4 b retinal detachment and required bilateral vitrectomy. Of the remainder, 45 cases had type 1 ROP, 16 had threshold disease, and 11 had AP-ROP. The median of gestational age was 26 weeks (range 23–30), and median of birth weight was 800 g (range 405–1350). Median follow-up was 10 months (range 6–8). The Teller test median was 3.2 cycles/cm (range 0.32–13). There were 16 (22%) cases with a myopic refraction of −6 D or more. The sphere median was −1.75 D (range −16.00 to +3.50 D) and the cylindrical median was 0.00 (range −4.5 to +1.5 D). Anatomical success was achieved in 71 (98.6%) of patients. Conclusion Treatment with laser or intravitreal bevacizumab is a highly successful primary treatment for ROP. Anatomical success can be achieved in most cases. Treated patients develop frequent and severe refractive defects, which should be corrected. Vision outcome, measured using the Teller preferential test, shows good results.