Abstract
In the historical mysteries and present pandemic situation, the use of citrus fruits makes it rise high among other fruits. Citrus has a significant role in dietary and medicinal purposes from time immemorial and widely acknowledged for its therapeutic properties. Citrus megaloxycarpa Lush. is an unspecified sibling of the citrus family. The present work highlights the biochemical, antimicrobial, and anticancerous potential of cryptic species indigenous to Northeast India. The research was done on peel; P(L1) and pulp; Pu(L2) extracts of ripe large and peel; P(L1) and pulp; Pu(L2) extracts unripe small varieties respectively. The extract of the Pu(L2) has the highest total soluble sugar (9.174±0.006741 μg/ml) whereas the extract of P(S1) demonstrated high protein concentration (8.074±0.0567 μg/ml). The total carbohydrate content also varied in the extracts; the extract of P(L1) showed (8.326±0.003844 μg/ml). P(L1) have high free amino acid content (24.35±0.0225μg/ml) and high free fatty acid exhibited on P(L2) (0.3739±0.05774 μg/ml). The total DPPH scavenging activity was compared for the extracts, where the extract of Pu (S1) exhibits highest activity 73.80% and 0.6577 of logIC50 value. The highest total antioxidant capacity displays 150±0.333 in P(L1). The MIC value was calibrated (30%, 35%, 40%, 45%) (v/v) and found to be maximum in P(L2) (0.695) and minimum in P(L1) (0.163) against Salmonella typhi and Escherichia coli. MTT assay showed highest viability rate of 94.32% and toxicity rate of 8.56% achieved on mouse lung cancerous cell. It is quite obvious from the present research that Citrus megaloxycarpa Lush. has a great scope at industrial level for developing therapeutic drugs.
Highlights
Citrus contains many phytochemicals such as vitamins, flavonoids, and phenolics compounds that are essential for carrying out different cellular activities to perform various physiological and enzymatic functions to prevent certain ailments in our busy lifestyle
The test organism used in this study includes both gram-negative and gram-positive bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Bacillus subtilis)
The total DPPH scavenging activity displays maximum activity of 73.80% with logIC50 of 0.6577 and total antioxidant capacity value of 150±0.333 μg/ ml; this demonstrates that it can be used for improving the immune response of the body against various ailments, such as COVID-19
Summary
Citrus contains many phytochemicals such as vitamins, flavonoids, and phenolics compounds that are essential for carrying out different cellular activities to perform various physiological and enzymatic functions to prevent certain ailments in our busy lifestyle. Higher adaptability of citrus in different climatic conditions governs its successful growth rate in tropical, subtropical, and in some temperate regions of the world. Their nutritional and medicinal values have made them remarkably important. Northeast India is paradise of many indigenous citrus species. It is considered one of the important fruit crops. Citrus is highly known for its nutritive value in Northeast India,the acidic nature of lemon makes it a preferable flavouring agent in dishes like vegetable, fish, meat, and salads,it is used in many Northeast Indian cuisines, in Manipur peels of sour pummelo are used for cooking purpose. Citrus megaloxycarpa Lush. is a rare, endangered species of citrus found in the northeastern part of Indian
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