Abstract
BackgroundTumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological subgroup were also vague based on tumor location. Our group focuses on the study of glioma anatomic location of distinctive molecular subgroups and histology subtypes, and explores the possibility of their consistency based on clinical background.MethodsWe retrospectively reviewed 143 cases with both molecular information (IDH1/TERT/1p19q) and MRI images diagnosed as cerebral diffuse gliomas. The anatomic distribution was analyzed between distinctive molecular subgroups and its relationship with histological subtypes. The influence of tumor location, molecular stratification and histology diagnosis on survival outcome was investigated as well.ResultsAnatomic locations of cerebral diffuse glioma indicate varied clinical outcome. Based on that, it can be stratified into five principal molecular subgroups according to IDH1/TERT/1p19q status. Triple-positive (IDH1 and TERT mutation with 1p19q codeletion) glioma tended to be oligodendroglioma present with much better clinical outcome compared to TERT mutation only group who is glioblastoma inclined (median overall survival 39 months VS 18 months). Five molecular subgroups were demonstrated with distinctive locational distribution. This kind of anatomic feature is consistent with its corresponding histological subtypes.DiscussionEach molecular subgroup in glioma has unique anatomic location which indicates distinctive clinical outcome. Molecular diagnosis can be served as perfect complementary tool for the precise diagnosis. Integration of histomolecular diagnosis will be much more helpful in routine clinical practice in the future.
Highlights
Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory
Tumor location remains consistently between histological subtype and its corresponding molecular subgroup glioma histology stratification strongly associated with molecular phenotype, we investigate whether anatomic distribution remains consistent within these two classification systems
Conclusion molecular biomarkers are getting involved in routine pathological diagnosis of cerebral diffuse gliomas, more evidence should be provided to validate perfect match between molecular subtypes and classic histological diagnosis
Summary
Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. The relationship between molecular phenotype and histological subgroup were vague based on tumor location. Our group focuses on the study of glioma anatomic location of distinctive molecular subgroups and histology subtypes, and explores the possibility of their consistency based on clinical background. Glioma is the most common malignant brain tumor with heterogeneous growth pattern which can be found in different cerebral lobes [1, 2]. This kind of locational variety has been demonstrated to be of great importance in patient diagnosis and prognosis which can reflect the tumor cells origin as well [3].
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