Abstract
Background and purposeLeft-sided breast radiotherapy (RT) can result in cardiac exposure. This study aims to identify predictive anatomic features in women requiring breath-hold (RTBH) for cardiac sparing during adjuvant whole breast RT. Material and methodsWe retrospectively reviewed free-breathing (FB) CT scans of 80 women previously treated with left-sided breast RT. Unfavourable cardiac anatomy was defined as the number of consecutive axial CT slices (2mm) in which the anterior chest wall contacted the heart (ContactHeart) or left ventricle (ContactLV). The sternal angle and Haller Index (HI) were used to measure chest concavity. Position and volume of post-operative cavity was also quantified. ResultsHeart mean dose (Dmean) was strongly correlated with ContactLV (r=0.625, p<0.001) and ContactHeart (r=0.524, p<0.001) but not significantly correlated with tumor size, cavity volume, heart volume, cavity distance to chest wall, sternal angle, or HI. ROC analysis of ContactHeart was most predictive of the need for breath-hold (RTBH) technique [Area Under Curve=0.815 (SE: 0.048; 95% CI: 0.721–0.91)] and ⩾25 ContactHeart CT slices predicted for heart Dmean ⩾1.7Gy (68% sensitivity and 82% specificity). ConclusionContactHeart on FB CT of ⩾25 axial slices (2mm), ⩾50mm of para-sagittal heart contact, was predictive of higher heart Dmean and suggest a potential need for RTBH.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.