Abstract
Although prostate cancer metastasizes primarily into the lymphatic system, the anatomic distribution of intraprostatic lymphatics has not been elucidated. The aim of this study was to clarify the distribution of lymphatics in the human prostate by immunohistochemical techniques, using an anti-desmoplakin antibody. Whole-mount cryostatic sections were serially cut from the noncarcinomatous prostates of adult men with bladder carcinoma who underwent cystoprostatectomy. Each section was stained either with a monoclonal antibody specific for desmoplakin or with hematoxylin and eosin. Lymphatics were detected in all components of the prostate. In the glandular prostate, lymphatics were distributed evenly in the peripheral, transitional, and central zones. The lymphatic density was significantly high in the midbase region surrounding ejaculatory ducts. These results may indicate the importance of the midbase region as a route of lymphatic spread of prostate cancer.
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