Abstract
Anaplastic Large Cell Lymphoma (ALCL) represents subgroupe of peripheral T-cell lymphoma and constitutes 10-12% of this group. According to WHO 2008 classification two types depending on presence of ALK gene rearrangement subdivide ALCL: ALK-positive (ALCL ALK+) and ALK-negative (ALCL ALK-). ALCL ALK+ has a favorable prognosis with CHOP in patients without adverse prognostic factors and event free survival (EFS) reaches 70-75%. ALCL ALK- has worse treatment results: when using CHOP overall survival (OS) and EFS does not reach more than 50%. Autologous stem cell transplantation (auto-SCT) in first complete remission takes an advantage.
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