Abstract
Aim: To describe a case of anaphylactic shock following the intravenous administration of vitamin K1Clinical features: A 64‐year‐old male was admitted to intensive care following repair of an aortic abdominal aneurysm. Intravenous amiodarone, ceftriaxone, vancomycin and metronidazole were commenced without incident. During the administration of intravenous vitamin K1 (phytomenadione, Konakion) the patient developed a rash, hypotension and severe bronchospasm.Outcome: The patient recovered following paralysis, manual ventilation, and standard medication for anaphylaxis.Conclusion: Intravenous administration of vitamin K1 and other drugs solubilised with polyoxyl 35 castor oil occasionally causes severe anaphylactic shock. A new colloidal formulation may reduce the hazards of intravenous vitamin K1 administration.Aust J Hosp Pharm 1997; 27: 146–7.
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