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Abstract
Mitotic kinesin Eg5 is an ATPase driven motor protein and it plays crucial role for spindle segregation during Eukaryotic cell division. Kinesin Eg5 is over expressed in cancer cell. Therefore, kinesin Eg5 is considered as a target of the cancer therapy. There are several types of well-known compounds have been utilized as Eg5 inhibitors, e.g. Monastrol, STLC (S-trityl-L cysteine), Ispinesib and so on. Althought the structure of these inhibitors are not conserved and displayed diversity. They bind to the same pocket of Eg5 composed of helix α2, helix α3 and loop 5.
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