Abstract
Hyperuricemia arises from the buildup of excessive uric acid in the blood, and it is implicated in the development of periodontitis. The objective of this study was to investigate the association between hyperuricemia and periodontitis using a cross-sectional study design and Korean Genome and Epidemiology Study Health Examinee (KoGES HEXA) data. This prospective cohort study used epidemiological data from the KoGES from 2004 to 2016. Among 173,209 participants, 8809 with hyperuricemia and 126,465 controls (non-hyperuricemia) were selected. This study defined hyperuricemia as >7.0 mg/dL of uric acid in men and >6.0 mg/dL in women. This study analyzed the history of periodontitis among hyperuricemia and control participants. Participants’ age, gender, income, obesity, smoking, alcohol consumption, and nutritional intake were all examined. Chi-square tests, independent t-tests, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of hyperuricemia for periodontitis was 0.89 (95% confidence interval (CI) = 0.81–0.96, p = 0.005). This study demonstrated that hyperuricemia was associated with periodontitis. This finding meant that elevated uric acid levels could have a positive effect on periodontitis. However, further studies should be performed to determine the range of uric acid levels beneficial to periodontal health.
Highlights
Hyperuricemia arises when there is excessive uric acid in blood
The objective of this study was to investigate the association between hyperuricemia and periodontitis using a cross-sectional study design and Korean Genome and Epidemiology Study Health
This study showed that the adjusted odds ratio (OR) (aOR) of hyperuricemia for periodontitis was lower in all patients than that of the control group (Table 2)
Summary
Hyperuricemia arises when there is excessive uric acid in blood. It activates the crystallization of uric acid in joints and extraarticular areas [1]. Elevated uric acid levels can lead to several diseases, including a painful type of arthritis called gout [2,3]. Accelerated purine degradation and higher production or reduced excretion of uric acid could cause elevated uric acid levels [5]. They are associated with health conditions such as cardiovascular disease, renal disease, metabolic syndrome, and diabetes [6,7]. At the normal human pH of 7.4, uric acid
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