Abstract
Background: Diabetes Mellitus type 2 is one of the complex diseases, affecting people both in developed and developing countries. Plant extracted compounds known as phytochemicals are worthy because they have various medicinal properties. Objective: The present study aims at the in silico discovery of novel potent inhibitors against Diabetes Mellitus type 2. Methods: A total of 2750 phytochemicals from various medicinal important plants were collected for this study. Origin of these plants was Pakistan and India. The ADMET, molecular docking approaches were used to determine the binding and reactivity of these phytochemicals as Diabetes Mellitus type 2 inhibitors. Results: The ADMET analysis and molecular docking resulted in the selection of 42 phytochemicals (3 against Glucokinase receptor, 22 against Fructose 1,6 Bisphosphate protein and 17 for multidrug-resistant protein) showing high binding affinity as compared to the previously reported inhibitors of Diabetes Mellitus type 2. Conclusions: These 42 phytochemicals can be considered novel inhibitors against Diabetes Mellitus type 2 and can be selected for additional in vitro and in vivo studies to develop a suitable drug against diabetes.
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