Abstract
Objective To determine the relationship between risk factors of CHD and clopidogrel resistance, and CD62p expression after PCI. Methods Forty-three patients who underwent PCI were drawn blood before taking clopidogrel and taking the drug one month later respectively. ADP-induced platelet aggregation was measured by the measurement of resistvity and CD62p was determined by flow cytometry. The incidence of clopidogrel resistance was evaluated by the precent reduction of PAGM. Correlation analysis was made between the risk factors of CHD and the incidence of clopidogrel resistance. Results Of 43 patients pretreated with 300 mg of clopidogrel>12 h prior to PCI and 75 mg the day of the PCI, 11 cases (25.4%) occurred clopidogrel resistance. Diabetes and TG increased clopidogrel resistance incidence, and cigarette smoking lowered the incidence. However, other risk factors studied in this research had no significant correlation with the incidence of clopidogrel resistance. A positive correlation was found between PAGM and CD62p. Conclusions Clopidogrel resistance occurs in some of the patients undergoing PCI. CD62p has a significant positive correlation with PAGM(more significant by percent ratio). Clopidogrel resistance can be determined by the percent reduction of CD62p. Key words: PCI; Clopidogrel resistance; PAGM; CD62p
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