Analytical study of gold-DNA nano core-shell cloaking characteristics for drug delivery and cancer therapy.

Abstract

The cloaking characteristics of biocells can be considered as a factor to determine drug absorption by the tissues. The metal-organic core-shell structure can act as a cloak around the molecules of tissue and can be used as a nanomachine for drug delivery. Thus, we define a ratio of drug absorption based on frequency red-shift and the effective permittivity in the optical spectrum. Here, a cylinder of molecules coated by plasmonic nano core-shells is proposed for measuring the cloaking characteristics of biocells. The overall bandwidth of the proposed cloak for reflectance less than -10 dB is 36%. We check the effect of the filling factors of nanoparticles on the reflection and the frequency response of the tissue. Besides the frequency red-shift and change in the level of reflection, the phase and impedance are extracted. We could obtain the normalized scattering cross-section of 5 dB lower than the cylinder without cloak for the cylinder with a gold-DNA core-shell cloak. Here, we modify the Maxwell-Garnett equation for a cylindrical structure to obtain the effective value of the permittivity for cancer and normal tissues. The results show that obtained permittivity from the simulation has a good match with the calculated permittivity from the Maxwell-Garnet equation. Therefore, this approach can be considered as an efficient method for drug absorption and diagnosis of cancer cells from normal cells.