Abstract
BackgroundA novel swine origin influenza virus (S-OIV) (H1N1) is spreading worldwide and threatens to become pandemic. ObjectivesDetermine analytical sensitivity of selected commercially available rapid influenza antigen detection tests in detecting S-OIV H1N1. Study designSerial dilutions of two S-OIV isolates, one seasonal influenza A (H1N1) isolate and a nasopharyngeal aspirate from a patient with S-OIV disease were tested in five commercially available influenza antigen detection tests and by virus isolation in cell culture. Viral M gene copy number was determined by quantitative PCR methods. ResultsThe analytical sensitivity of the five influenza antigen detection tests for S-OIV (tissue culture infectious dose 50 (TCID50) log103.3–4.7 was comparable with that of seasonal influenza (TCID50 log104.0–4.5). ConclusionThe analytical sensitivity of the selected influenza A antigen detection tests for detection of S-IOV was comparable with that of seasonal influenza H1N1.
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