Abstract
Analytical Performance Assessment of the Prothrombin Time and Activated Partial Thromboplastin Time Tests by Roche Cobas t511 Coagulation Analyzer
Highlights
With Passing and Bablok regression analysis, for prothrombin time (PT) (Fig. 1A) yielded the equation of y = 1.015 ×–2.70; international normalized ratio (INR) (Fig. 1B) yielded the equation of y = 1.05 ×–0.0198; activated partial thromboplastin time (aPTT) (Fig. 1C) yielded the equation of y = 1.571 × −8.029
Cobas t511 is a medium throughput (195 tests/hour) coagulation analyzer that provides performing a wide range of different coagulation assays on a single or multiple samples at the same time
Lippi et al found the automatic resuspension of PT on the Cobas t711 platform with a variation of 0.04%
Summary
Aim and objective: The study aims to evaluate the performance of a newly installed fully automatic coagulation analyzer Roche t511. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are often measured in clinical practice. They are commonly used in the assessment of coagulopathies, the activity of anticoagulant therapy, and preoperative screening.[1,2] The clinical interpretation of coagulation test results depends on established reference intervals derived from clinical studies in healthy populations. The study aims to evaluate the performance of a newly installed fully automatic coagulation analyzer t511 (Roche) and compare the consistency of its testing results with the confirmed clinical automatic coagulation analyzer Sysmex CS 2000i (Siemens) at our laboratory
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