Abstract
This short review is limited to enzyme inhibitors with a carbohydrate or pseudosaccharide structure. It describes the physical methods used to isolate the substances and determine their physicochemical properties: column chromatography for isolation, liquid and gas chromatography for separation and quantification, special preparative methods such as Craig distribution, and spectroscopic techniques for structure determination. Individual data such as melting points, boiling points, and specific rotations have not been compiled, since they are not very informative for such diverse chemical species. Summaries of all the physicochemical properties of the individual glucosidase inhibitors can be found in the original literature, cited in Chap. 15, this volume, e.g., for acarbose in Takahashi et al. (1989). Nuclear magnetic resonance (NMR) and mass spectroscopic data for MDL 25637 (Merrell-Dow) have been described by Anzeveno et al. (1989) and LIU (1987). The physicochemical properties including NMR data to AO 128 (Voglibose) were presented by Fukase and Horii (1992)
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