ANALYTICAL METHODS FOR THE QUANTITATION OF AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM IN PHARMACEUTICAL DOSAGE FORM AND BIOLOGICAL FLUIDS

Sk Manirul Haque,Murad Alsawalha

doi:10.22159/ijap.2019v11i3.32566

Sk Manirul Haque, Murad Alsawalha

Open Access

https://doi.org/10.22159/ijap.2019v11i3.32566

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Abstract

Amlodipine is the best-prescribed medication for cardiovascular disease major risk factor for hypertension and atorvastatin well known for diabetic. First discussed low cost ultraviolet-visible technique for the determination and quantitation of drugs in pharmaceuticals and biological fluids. Chromatographic techniques have an application with respect to trace analysis. Different types of chromatography such as high-performance liquid chromatography, high performance thin layer chromatography have most frequent applications in the field of pharmaceutical as well as biomedical analyses. Chromatography combined with mass spectrophotometry has the ability to collect molecular ion, followed to prepare a spectrum to assess molecular weight as well as structure. High-performance liquid chromatography coupled with mass spectrophotometry is a reliable and dynamic technique for the analysis of small and large drugs molecule. The advantages and disadvantages of all techniques are compared with each other with respect to sensitivity, reproducibility and other important parameters. The investigation also focused for the quantitation on both drugs in pharmaceutical preparations and plasma samples with the help of all available analytical techniques.

Highlights

Amlodipine besylate is scientifically known as (RS)-3-ethyl5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro -6-methyl-3,5-pyridinedicarboxylate benzene sulfonate
High-performance thin layer chromatography (HPTLC) can be applied as an alternative option for traditional Thin-layer chromatography (TLC) method
The main objective of this review is to provide sufficient information for the researcher, academic, scientist about the analysis of important calcium channel and statins receptor

Summary

Introduction

Amlodipine besylate (fig. 1a) is scientifically known as (RS)-3-ethyl5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro -6-methyl-3,5-pyridinedicarboxylate benzene sulfonate. 1a) is scientifically known as (RS)-3-ethyl5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro -6-methyl-3,5-pyridinedicarboxylate benzene sulfonate. It was first introduced and prescribed for coronary artery disease. The number will increase with time and expected by the year 2025, approximately 1.56 billion [2]. This drug is under the umbrella of calcium channel blocker. The mechanism of such blockers to control the transportation of calcium to coronary (mainly smooth muscle) and arteries, that reflects on muscles became relaxes, reduces peripheral resistance and lowering the blood pressure [3]. Atorvastatin (fig. 1b) is chemically known as (βR, δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-1heptanoic acid

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Conclusion