Abstract
Aminoglycosides antibiotics are considered to be the antimicrobial agents used frequently in the treatment of human diseases caused by a bacterial infection. Most of the aminoglycosides antibiotics are highly polar in nature and they are lacking the UV absorbing chromophore in the molecules. The present articles accentuate the analytical method associated with the analysis of aminoglycosides molecules. Various chromatographic techniques like liquid chromatography, gas chromatography; mass spectrometry were used for the detection of aminoglycosides antibiotics. However, due to its limitation in the ultraviolet-visible spectrophotometry (UV/Vis) technique, different types of detection techniques like corona-charged aerosol detector (CAD), electrochemical detector (ECD) were used as a most powerful and versatile technique for the demonstration of these molecules in the analytical field. Analytical methods help to ensure the quality of the drug products. This review paper is devoted to providing an overview of the key performance technique used for the application and detection of these aminoglycosides molecules.
Highlights
Aminoglycosides are a group of highly potent antimicrobial agents used frequently in the treatment of human-caused by both gram-positive and gram-negative bacterial infection
Streptomycin is the foremost antibiotics isolated from Streptomyces griseus and it is active against gram-negative bacteria, which were used in clinical studies in 1944, followed by neomycin from Streptomyces fradiae, kanamycin from Streptomyces kanamyceticus, gentamicin from Micromonospora purpurea, sisomicin from Micromonospora inyoensis [1, 2]
Most of the aminoglycoside antibiotics are derived by the fermentation process
Summary
Aminoglycosides are a group of highly potent antimicrobial agents used frequently in the treatment of human-caused by both gram-positive and gram-negative bacterial infection. This class of antibiotics has imperative solicitation in veterinary medicine. Aminoglycosides molecules contain aminocyclitol and an amino sugar joined to a ribose unit. They interfere with bacterial protein synthesis by binding irreversible to ribosomes. Aminoglycosides antibiotics have lots of contribution towards the health of human and animals. Chromatographic technique especially high-performance liquid chromatography considered to be used mostly for the analysis of these aminoglycosides
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