Abstract
A simple, rapid and precise ultraviolet spectroscopy method was developed and validated for quantitative analysis of irbesartan in bulk drug. It is an angiotensin II receptor (AT1 subtype) antagonist. It is used for the treatment of hypertension. It shows maximum absorbance at 246 nm. Beer Lambert's was obeyed in the concentration range of in the range of 5–30 μg/ml. The method was successfully validated in accordance to USP pharmacopeia and ICH guideline for accuracy, precision, rang and linearity. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor is greater than 0.999 for irbesartan. The % Recovery/Accuracy was within the range between 98% and 102%. The percentage RSD for precision was found to be less than 2%. Thus method was successfully applied for routine analysis of irbesartan in bulk samples.
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