Abstract
Thiocolchicoside a natural anti-inflammatory glycoside. It is the semi-synthetic derivative of the colchicine. It is a muscle relaxant with anti-inflammatory and analgesic effects. It works through selective binding to the GABA-A receptor. It prevents muscle contractions by activating the GABA inhibitory motor pathway. The article summarizes analytical method including the chromatographic method, LC-MS (Liquid Chromatography-mass spectroscopy), HPLC, GC-MS (Gas chromatography-mass spectroscopy), HPTLC and UV-Visible spectrophotometry techniques for estimation of Thiocolchicoside in biological samples, bulk and pharmaceutical formulation.
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