Abstract
Metaxalone, a muscle relaxant used to relax muscles and relieve p ain caused by strains, sprains and othermusculoskeletal conditions. A simple, accurate, precise, reproducible, highly sensitive, economic UV spectro photometric method has been developed for the estimation of metaxalon in bulk and tablet dosage form. In this method metaxalon showed maximum absorbance at 280 nm in methanol. The developed spectrophotometric method was validat ed in accordance with ICH gui delines. Linearity of the method was found to be 5 - 160µg/ml. The method obeyed Beer’s law in the concentration range of 5 - 160 µ g/ml. The LOD and LOQ were found to be 3.489 μ g/ml and 10.575μ g/ml respectively. A mean recovery of metaxalon in tablet dosage form was found to be 99.69 %.the method was found to be simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to tablet d osage fo rm.
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