Analytical Method Development and Validation of Lead Content in Cellulose Hydroxyethylate with Internal Standard Ratio Method by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Abstract

A thickening and gelling agent made from cellulose is called cellulose hydroxyethylate. In the formulation of capsules, cellulose hydroxyethylate is commonly utilised with hydrophobic medications. Lead is highly dangerous; its usage can pollute the environment, endanger human health, and alter entire ecosystems. A method was developed and put into use for routine analysis to determine the lead content in cellulose hydroxyethylate using ICP-MS. Lead metal, as classified as a hazardous metal by USP (233), was used in this investigation. The lead metal recuperation rates were found to be between 70 to 150 percent. After a summary, it can be said that the analytical methods for determining the mass fractions of lead elements in cellulose hydroxyethylate that have been described.