Abstract
A Simple, definite, informal, rapid, precise and accurate UV Spectrophotometric analytical method have been developed and Validated for estimation of Hydrochlorothiazide formulation drug. Hydrochlorothiazide showed the absorption maxima in at 271.0 nm and was linear for a range of 5µg/ml-25µg/ml with correlation coefficient of 0.9995. The validation for the proposed analytical method was performed by using precision and accuracy-recovery studies. The analytical method showed good Intra precision (Repeatability) with relative standard deviation 0.563% and Inter precision with relative standard deviation is 0.634% which is within 2. The percentage of accuracy-recovery for three different levels i.e. 50%, 100% and 150% was found to be 50.1%, 99.5% and 151.1% respectively. The proposed analytical method was validated for the parameter Specificity, Precision, Linearity and range, Ruggedness, Accuracy and recovery. Hence projected analytical method for estimation of Hydrochlorothiazide formulation drug using UV spectrophotometer in pharmaceutical can be functional for the routine excellent analytical study.
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