Abstract
Purpose: The aim of the present study was to evaluate the efficacy of hepatitis C virus [HCV] core Ag assay by comparing it with anti-HCV antibodies and PCR-based technology for measuring viral load in diagnosis of HCV. Study design: HCV core Ag by ELISA in serum, in the presence or absence of antiHCV antibodies was compared to HCV- RNA by PCR on total number of 100 subjects, divided into 3 groups; including 80 patients and 20 volunteers. Results: The sensitivity of the test was (72.5%) and the specificity was (86.6%). Also positive predictive value of the test was (78.3%) and negative predictive value was (82.5%). Conclusion: Core antigen detection by ELISA can be used as a reliable test for detection of vireamia in HCV infection.
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