Abstract
Introduction: Continuous subcutaneous insulin infusion (CSII) is a form of insulin administration for patients with type I diabetes mellitus (T1DM) that was introduced as a means of stimulating normal plasma insulin fluctuations and provide better metabolic control that is better than multiple daily insulin injections (MDI). The purpose of this study was to determine the effect of CSII as compared to MDI in the treatment of T1DM in children and adolescent below 20 years of age.
Highlights
Continuous subcutaneous insulin infusion (CSII) is a form of insulin administration for patients with type I diabetes mellitus (T1DM) that was introduced as a means of stimulating normal plasma insulin fluctuations and provide better metabolic control that is better than multiple daily insulin injections (MDI)
The data reviewed showed that CSII and MDI have similar efficacy in terms of reducing the incidence of hyperglycemia with no significant differences in pre-meal hyperglycemia and overall hyperglycemia for patients who adhered to their treatments [15,2124]
A study done by Little SA, et al on 96 participants randomized to receive CSII or MDI found significantly higher treatment satisfaction with CSII (P=0.0003) [25]
Summary
Continuous subcutaneous insulin infusion (CSII) is a form of insulin administration for patients with type I diabetes mellitus (T1DM) that was introduced as a means of stimulating normal plasma insulin fluctuations and provide better metabolic control that is better than multiple daily insulin injections (MDI). According to the SEARCH for Diabetes in Youth Study, approximately 18,000 children and adolescents younger than years of age are diagnosed with T1DM annually with the highest rate in non-Hispanic Whites.Strikingly, while the reported incidence of T1DM was about per 100,000 in all races it was 26 per 100,000 among Non-Hispanic Whites [4]. This is the largest ethnic group in the Americas and Europe
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