Abstract
Main approaches to the determination of low-molecular-weight chemical compounds by surfaceassisted laser desorption/ionization (SALDI) are considered. Analytes are adsorbed from a gas phase on the surface of a specially prepared solid-state substrate. Then, the surface is exposed to pulse laser radiation, which leads to ionization and desorption of ions to be detected with a mass analyzer. The factors responsible for the efficiency of ionization are examined, the instrumental versions of SALDI are presented, and the metrological characteristics of this method are given. The high ionization efficiency of basic compounds, which is higher than the efficiency of traditional ionization methods by orders of magnitude, the mild conditions of ionization, the simplicity of performance, and the possibility of combinations with analyte separation systems characterize SALDI as an exceptionally promising method for the determination of low-molecular-weight volatile compounds.
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