Abstract
The presented review is devoted to analytical applications of reactions of Fe(III) and K3[Fe(CN)6] with 2,10-disubstituted phenothiazines (PT). It was found that iron(III) and hexacyanoferrate(III) ions in acidic media easily oxidized PT with the formation of colored oxidation products. This property has been exploited for spectrophotometric determination of iron(III) ions and phenothiazines. Some flow-injection procedures of the determination of PT based on the oxidation reaction by means of the above-mentioned oxidants have been proposed. In the presented review, the application of 2,10-disubstituted phenothiazines as indicators in complexometric titration of iron(III) as well as procedures of PT determination based on generation of ternary compound in the system Fe(III)-SCN−- PT was also described.
Highlights
Phenothiazines constitute one of the largest chemical classes of organic compounds in official compendia
Over 4 thousands compounds have been synthesized and about 100 have been used in clinical practice [1]. 2,10-Disubstituted phenothiazines are very important drugs which are widely used in psychiatric treatment as tranquillizers
In our previous works [14, 15], we have described the optimal conditions for the formation of colored products of 2,10-disubstituted phenothiazines with FeCl3 and K3[Fe(CN)6] in acidic media
Summary
Phenothiazines constitute one of the largest chemical classes of organic compounds in official compendia. Phenothiazines have exhibited complexing properties due to the presence of the condensed three-ring aromatic system and amine nitrogen atom in a side chain in position 10 They have reacted with some metal ions or thiocyanate complexes of metals forming colored, hard soluble in water but easy soluble in organic solvents compounds [1, 10]. The oxidation reaction conducted in the system Fe(III)-NO3−CIO4− (Forrest’s reagent) is still used for quick examination of presence of phenothiazines in studied sample [24]. The most important property of phenothiazines is their susceptibility to oxidation by many oxidizing agents, for example, Fe(III), [Fe(CN)6]3− with the formation of colored oxidation products (free radicals) in acidic media [8, 21]. The oxidation properties of iron(III)-phenothiazines system have been employed for the spectrophotometric determination of iron(III) ions [16] and diethazine [18]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
