Abstract
Capillary chromatographic analyses of thermally labile, less volatile and higher molecular weight compounds can be accomplished using supercritical mobile phases due to the combination of solvating powers and attractive mass transport properties. Recent advances in the use of small bore (25–50μm) capillary columns, rapid pressure programming methods, and polar mobile phases have yielded high-sensitivity and high-speed analyses with chromatographic resolution approaching that of conventional capillary gas chromatography. Mass spectrometry (MS) provides a nearly universal detector for supercritical fluid chromatography (SFC), and the ease with which capillary SFC can be directly coupled with the mass spectrometer avoids the complications inherent in liquid chromatography (LC)—MS interfaces. Capillary SFC can be interfaced with both electron impact and chemical ionization (CI) modes of operation, and high selectivity and sensitivity as well as structural data can be obtained through appropriate choice of CI reagents. Recent developments in capillary SFC—MS and applications to several compound classes are described.
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