Abstract
The reaction of Ethyl 5-(piperidin-1-yl-methyl)furan-2-carboxylate with 4-amino salicylic acid afford a 4-(5-((diphenylamino)methyl)furan-2-carboxamido)-2-hydroxybenzoic acid (PFSA). The transition metal complexes of Cu<sup>2+</sup>, Co<sup>2+</sup>, Ni<sup>2+</sup>, Mn<sup>2+</sup> and Zn<sup>2+</sup> of PFSA have been prepared. The objective of the research work is synthesis, characterization and chelating properties of furan ring containing organic ligands. To monitor its antimicrobial activity. PFSA and all the metal complexes were characterized by elemental analyses, spectral studies, magnetic moment determination, molar conductivity measurement. The free ligand and it’s complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria the first group is gram positive while the second group is gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria. The conclusion is Ni (II) Cu (II), Co (II) and Mn (II) complexes possess octahedral geometry around the central metal ion.
Highlights
Literature survey point out that compounds having furan nucleus possesses some diverse biological activities and chemical applications [1] like antimicrobial [2], anthelmintic [3], anti-inflammatory [4], diuretic [5], analgesic [6]
IR spectra of PFSA and its metal complexes were scanned on a Nicolet 760 FTIR spectrophotometer in KBr
The metal content of the metal chelates was performed by decomposing a weighed amount of each metal complexes followed by EDTA titration as reported in literature (Hong et al, 2008)
Summary
Literature survey point out that compounds having furan nucleus possesses some diverse biological activities and chemical applications [1] like antimicrobial [2], anthelmintic [3], anti-inflammatory [4], diuretic [5], analgesic [6]. The salicylic acid and its derivatives like 4amino salicylic acid act as good chelating agents [7, 8], as well as potential pharmaceutical products [9, 10]. The reaction between furan derivative with 4-amino salicylic acid (ASA) has not been reported so far. 4-amino salicylic acid is an excellent anti T. B agent and acts as a chelating ligand with better microbicidal activity. It was thought interesting to prepare the intermolecular ligands containing furan and salicylic acid moieties. The present communication comprises the studies on furansalicylic acid combined molecule and its metal chelates. The obtained metal complexes were characterized by different analytical and spectral methods. Patel: Analytical and Spectral Study of Furan Ring Containing Organic Ligands
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