Abstract
Paraquat (PQ) residue is harmful for people's health. This work fabricated an efficient approach to determine PQ sensitively. We exploited a novel surface plasmon resonance (SPR) detection system based on the analyte induced network architecture of supermolecules modified gold nanoparticles (AuNPs) on the chip surface. para-Sulfonatocalix[4]arene (pSC4) were used as a recognition molecule for paraquat. PQ can mediate the aggregation of pSC4 capped AuNPs (pSC4-AuNPs) through the host-guest recognition, which can be used as signal amplification for PQ assay. This achievement is due to several outstanding properties of this detection system: first, local SPR and high refractive index of AuNPs can enhance the signal of SPR dramatically; second, AuNPs is more stable and biocompatible and diffusely used in colorimetric methods; third, the network AuNPs structure has unique photo characterization for enhancement of SPR. Analyte induced AuNPs aggregation amplified SPR assay shows dramatic signal enhancement ability. The detection limit for PQ was found to be 2.2 pM This strategy provides a new concept for developing sensitive SPR sensors for the highly selective detection of small molecules.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
