Analysis on the results of the second-line drug susceptibility testing in the MDR-TB patients in Shantou

Abstract

Objective To analyze resistant situation to second-line anti-TB drugs of mycobacterium tuberculosis among inpatients with MDR-TB in the Third People's Hospital of Shantou,and provide the evidence for making the treatment regimens.Methods The analysis was conducted on drug susceptibility testing to Am,Lfx and Pto of mycobacterium tuberculosis among 135 inpatients with MDR-TB from Aug 1 st,2010 to Jul 31st,2012.The second-line drug resistance rate of new treatment group and re-treatment group were observed.Results The secondline drug resistance rate of Lfx,Am and Pro in new treatment group were 10.0％,10.0％ and 6.7％ respectively,23.8％,17.1％ and 4.8％ respectively in re-treatment group.There were no XDR-TB patients in new treatment group,and 13 XDR-TB patients (accounting for 12.4％) were found in re-treatment group.Conclusion The second-line anti-TB drug susceptibility testing will help us to make the individual treatment regimens for the MDR-TB patients. Key words: Tuberculosis; Pulmonary; Mycobacterium tuberculosis; Drug resistance