Analysis on the relationship between serum alanine aminotransferase and impaired fasting glucose

Abstract

To investigate the correlation of serum alanine aminotransferase (ALT) level with impaired fasting glucose (IFG) and evaluate the modification effects of body mass index in Chinese adults. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China. A total of 32 433 subjects with biomarkers available were included in the present study. Serum ALT, triglyceride, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, and glucose levels were measured. IFG was defined as from 6.1 mmol/L to 7.0 mmol/L. Results are expressed as ±s. The correlation between serum ALT and impaired fasting glucose was assessed using logistic correlation. The correlation of serum ALT and IFG in the group of fasting blood glucose was segnificantly (r=0.07, P 0.05). After adjusted for age, sex, and body mass index, there was a strong correlation between the fasting blood glucose (r=0.04, P<0.01) in ALT and IFG group. After further adjustment for serum lipids, blood pressure, this correlation still exists (r=0.03, P<0.01). Body mass index influences correlation of ALT and IFG. The present data indicate that the serum ALT is related to the risk of IFG in Chinese adults, and body mass index level may affect the relationship.(Chin J Endocrinol Metab, 2015, 31: 1034-1037) Key words: Diabetes mellitus, type 2; Alanine aminotransferase; Bady mass index; Impaired fasting glucose