Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13

Abstract

Asthma is one of the global health issues that occurs in both developed and developing countries. There are a few ways to classify asthma, based on clinical presentation and spirometry, based on immunologic reaction using Interleukin 4 (IL-4), Interleukin 13 (IL-13) and Eosinophil Cationic Protein as chronic respiratory tract inflammation markers. Observational study was held using a cross-sectional design among 46 patients diagnosed with chronic asthma at Dr. M. Djamil General Hospital. Data analysed was using t-test to found relationship between chronic asthma with IL-3 and IL-4. Among 46 patients, 23 samples were mild chronic asthma, 72% of the sample were women (p=0,190), age of the patients with mild chronic asthma was 24,96 years old ± 7,64 year SD, while severe chronic asthma were 29,52 years old±8,88 year (p= 0,232). Interleukin 4 (IL-4) was found less in mild chronic asthma than the severe one, 3,44 (±0,73) pg/ml and 3,64 (±1,11) pg/ml respectively.IL-13 in mild chronic asthma was in the higher level than in the severe ones. The level of IL-4 was 295,23 (±2,38) pg/ml in mild chronic asthma, while the level of IL-13 in severe chronic asthma was less than the mild ones, 294,21 (±3,24) pg/ml. There is no significant relationship between the severity of chronic asthma based on spirometry and level of Interleukin 4. Interleukin 13 was significantly related to chronic asthma