Analysis on the refractive state after treatment of retinopathy of prematurity

Abstract

Objective To analyze the refractive state of retinopathy of prematurity (ROP)after different methods of treatment . Methods The data of 114 eyes of 60 cases with ROP from 2013 to 2016 were analyzed retrospectively. All cases were divided randomly into laser treatment group and intravitreal injection group . The cycloplegic retinoscopy refraction data of children at 24 months were collected. The refractive status and related factors of the two groups were statistically analyzed. Results The incidence rate of high myopia and astigmatism in laser treatment group were higher than those of intravitreal injection group, the difference were significant between the two groups (χ2=7.828, 2.705; P=0.000, 0.007). In laser treatment group the spherical equivalent refraction were smaller, the average column mirror degree were smaller and the axial length was longer, the difference were statistically significant between the two groups (χ2=2.329, 0.384, 2.184; P=0.034, 0.007, 0.039) .The differences in the incidence of hyperopia and myopia after treatment were statistically significant between multiple intravitreal injection and single injection(χ2=2.274, 3.052; P=0.023, 0.002 ). The spherical equivalent refraction were smaller and the axial length were longer in multiple intravitreal injection group, the differences were statistically significant(χ2=0.944, 2.381; P=0.036, 0.042). Conclusion The incidence of myopia and astigmatism are lower after inteavitreal injection for the treatment of ROP, and the effect of vision acuity is small. The incidence of myopia and astigmatism in ROP children treated with intravitreal injection is higher than that of single vitreous body injection for ROP. Key words: Retinopathy , prematurity; Treatment , laser; Intravitreal injection; Refraction