Analysis on the Molecular Interactions between Tobramycin, an Aminoglycoside Antibiotic and Periplasmic Glucans Isolated from Pseudomonas syringae

Abstract

The chemical structures of these molecules are shown in Figure 1. Tobramycin (Figure 1A) consists of three rings of nebrosamine (a), 2-deoxystrapt-amine (b), and kanosamine moiety (c). Linear β-glucans (Figure 1B) are β-1,2 linked and β-1,6 branched glucans containing 6-12 glucose residues.NMR spectroscopic analysis is a technique providing the evidence of complexation