Analysis on the efficacy of biological amniotic membrane transplantation for complicated ocular surface diseases

Abstract

Objective To evaluate the clinical efficacy of biological amniotic membrane transplantation in complicated ocular surface disease and ocular surface reconstruction. Methods The data of 74 eyes of 74 patients with complicated ocular surface disease from Jan. 2011 to Dec. 2016 were analyzed retrospectively. They underwent biological amniotic membrane transplantation. Results The most common primary diseases was recurrent pterygium in 25 eyes (33.78%), followed by corneal ulcer in 20 eyes (27.03%), chemical injury in 15 eyes (20.27%), symblepharon in 10 eyes (13.51%), persistent epithelial defects (PED) in 2 eyes (2.70%), eyelid basal cell carcinoma in 1 eye (1.35%) and Stevens-Johnson syndrome (SJS) in 1 eye (1.35%). After 6 - 24 months follow-up, there were 12 eyes (16.22%) reoperated, including pterygium recurrence in 3 eyes (3/25, 12.00%), corneal ulcer in 2 eyes (2/20, 10.00%), chemical injury in 4 eyes (4/15, 26.67%), symblepharon in 2 eyes (2/10, 20.00%), SJS 1 in eye (1/1, 100.00%). No infection, graft rejection or allergic reaction after surgery occurred. Conclusion Amniotic membrane transplantation is an effective method for the treatment of complicated ocular surface diseases. Key words: Transplantation, biological amniotic membrane; Diseases, ocular surface; Pterygium; Ulcer, corneal; Injury, chemical