Analysis on the current situation and influencing factors of antiviral drug compliance in patients with e-antigen negative chronic hepatitis B patients who use nucleos (t) -ide analogues

Abstract

Objective To survey the effects of nucleos (t) -ide analogues on the drug compliance of patients with e-antigen negative chronic hepatitis B patients and its influencing factors. Methods A retrospective survey was used to investigate consecutive patients who were hospitalized in our hospital from January 2008 to December 2009. Telephone interviews, medical inquiries, questionnaires and follow-ups were used to collect patients′ general information, which included general demographic information, medical history, and hepatitis B knowledge questionnaire. Results Follow-up data were collected from 327 compliance cases, which included 149 cases of good compliance and 178 cases of poor compliance. The compliance ratio was 45.57%. There were significant differences between good compliance group and poor compliance group in education background, economic status, insurance type, and the knowledge about hepatitis B (P<0.05) . Binary Logistic regression analysis showed that high-income level, good knowledge about hepatitis B were the independent risk factors of high compliance (P<0.001) . Conclusions The drug compliance of patients who use nucleos (t) -ide analogues to treat e-antigen negative chronic hepatitis B is poor, and we should strengthen the health education to improve the drug compliance of using nucleos (t) -ide analogues. Key words: E-antigen; Hepatitis B, chronic; Nucleos (t) -ide analogues; Drug compliance