Analysis on the clinic and pathologic features of hypertension patients with ACTH-independent adrenal hyperplasia

Abstract

Objective To investigate clinical and pathologic features of hypertension patients with adrenoeorticotropic hormone(ACTH)-independent adrenal hyperplasia, and to analyze the relationship between them. Methods The data of patients with ACTH-independent adrenal hyperplasia and hypertension was collected in Department of Urology, the First Affiliated Hospital of Zhengzhou University from Jan. 2012 to Dec. 2012. The clinical manifestations, endocrine examination results, imaging findings and the pathological changes of adrenal gland were retrospectively analyzed. Results 75 cases were followed-up. Among them, 39 cases were male and 36 were female. Their ages ranged from 20 to 74 years(with 47 as the average). Pathological results showed that diffusive hyperplasia was observed in 42 cases, tubercle hyperplasia in 26 cases, mixed corticomedullary pathological changes in 6 cases, and medullary hyperplasia in 1 case. No significant difference was found among diffusive, tubercle and mixed corticomedullary hyperplasia in clinical manifestations except for headache, endocrine examination results, or imaging findings(P>0.05). Conclusion There is no relation between clinical manifestations, endocrine examination results, imaging findings and pathological changes in adrenal gland for patients with ACTH-independent adrenal hyperplasia and hypertension. Key words: ACTH-independent; Adrenal hyperplasia; Pathologic; Hypertension