Abstract
Objective: To investigate factors contributed to anti-infection efficacy of fluoroquinolones (FQNS), and ultimately to provide guidelines for the application of such drugs. Methods: Clinical data of 519 infected patients who were treated with fluoroquinolones were analyzed retrospectively. According to the therapeutic efficacy of the drugs, cases were divided into 3 groups: clinical inefficient, improved and cured. 11 potential factors were investigated. The data were analyzed through logistic regression analysis to determine the main factors which influence therapeutic effects. Results: Ordinal logistic regression revealed that age (OR = 0.979, 95% CI: 0.969, 0.989), a variety of medicine (moxifloxacin-OR = 3.465, 95% CI: 1.396, 8.601; levofloxacin-OR = 4.605, 95% CI: 1.971, 10.760; ciprofloxacin-OR = 3.220, 95% CI: 1.089, 9.552; compared to lomefloxacin) (levofloxacin-OR = 2.591, 95% CI: 1.130, 5.944; compared to fleroxacin) and site of infection (respiratory system-OR = 3.016, 95% CI: 1.737, 5.236; urological system-OR = 4.077, 95% CI: 1.981, 8.391; digestive system-OR = 3.740, 95% CI: 1.849, 7.565) are main factors which influence the efficacy. Conclusion: Fluoroquinolones are more effective in the treatment of bacterial infection within drug’s indications in young population. Variety, dosage and intervals of the drugs should be adjusted according to disease condition.
Highlights
Since the first quinolone, nalidixic acid, was released for treatment of urinary tract infection as a new class of antibiotic agents in 1962 [1], it has been almost half century
After analyzing the correlation of the two factors, we found that moxifloxacin were principally used in respiratory infection and lomefloxacin were for other infection from Burn and Plastic Surgery Dept
A variety of medicine and sites of infection were the influential factors of efficacy of fluoroquinolones in anti-infective treatment
Summary
Nalidixic acid, was released for treatment of urinary tract infection as a new class of antibiotic agents in 1962 [1], it has been almost half century. Fluoroquinolones have been commonly used in adults for the treatment of a wide range of infections. After the widespread but indiscriminate use of fluoroquinolones, bacterial with resistance and decreased suscep-. Tibility to fluoroquinolones have been increasingly reported in recent years [5,6,7,8]. More and more excellent work has been mainly devoted to the synthesis and activitystudy of new fluoroquinolones, revealing the mechanism of drug resistance, etc. We aimed to find how to properly and reasonably apply fluoroquinolones to reduce drug resistance. We adopted regression analysis to identify the dominant factors which influence the result of treatment
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