Analysis on human papillomavirus infection in 2 110 patients with cervical cancer in Henan province

Abstract

Objective: To explore human papillomavirus (HPV) infection status in 2 110 patients with cervical cancer in Henan province and analyze the main infection subtypes. Methods: A total of 2 110 patients with cervical cancer were detected for HPV subtypes by flow-through hybridization after PCR. The results were analyzed. Results: Among 2 110 patients with cervical cancer, 1 856 were detected to be HPV positive and the infection rate was 87.96%(95%CI: 86.57%-89.35%). The top six genotypes were HPV16, 58, 18, 52, 35 and 33. Single infection was the main type of infection in HPV positive cervical cancer patients (77.48%), and double infection was the second type infection(16.76%). The infection rate of HPV16 was 60.19%, occupying a predominant position in single or multiple infections. Among HPV positive cervical cancer patients, 1 599 cases were detected to be infected with high-risk subtypes and covered by nine-valence HPV vaccine, and the coverage rate reached 86.15% (1 599/1 856). Cervical cancer patients were mainly distributed in age group 40- years. The main HPV subtypes of cervical cancer patients were different among different age groups, but HPV16 subtype was in a predominant position in any age group. Conclusions: The main subtypes of HPV infection were HPV16, 58, 18, 52, 35 and 33 in cervical cancer patients in this study. The main infection type was single infection. There were more cervical cancer patients in age group 40- years.