Analysis on factors affecting the clinical carative effect and prognosis for partial cystectomy and adjurant chemotherapy in pelvic lymph node negative muscularis invasive bladder cancer

Abstract

Objectives To study the treatment effect of bladder resection plus chemotherapy to the muscular layer of pelvic lymph node negative invasive bladder cance,to report the effectiveness of the treatment method and to investigate the prognostic factors.Methods Selecter from February 2008 to our hospital oncology has implemented a muscle invasive bladder cancer partial cystectomy plus adjuvant chemotherapy and clinically relevant information on persons,50 cases were included as a treatment group.To select the same period,while the muscle to accept radical cystectomy for invasive bladder cancer treated 50 cases of people as a control group,and carefully collect clinical data.The treatment group and the control group were analyzed efficiently.Risk factors for analyzing the impact of pelvic lymph node-negative muscle invasive bladder cancer,the authors further analyzed by logistic regression.Results The results showed that the treatment group was the Institute's effective rate of 87.50％,the effective rate was 83.33 ％ in the control group,two groups that the treatment group and the control group do not exist in terms of an efficient statistical difference(P ＞ 0.05) but by staging comparison,we obtained highly selective group of patients was significantly higher efficiency and statistically significant(P ＜ 0.05).Logistic regression analysis was measured pathological grade(P =0.001,P ＜ 0.05) and pathological stage (P =0.002,P ＜ 0.05) were independent risk factors for the pelvic lymph node-negative muscle invasive bladder cancer.Conclusions In this study,partial cystectomy with adjuvant chemotherapy treatments to contrast display,partial resection of bladder surgery adjuvant chemotherapy compared with radical cystectomy treatment of muscle invasive bladder cancer in all pathological grading and no advantage,but the use of the highly selective partial bladder surgery in patients with adjuvant chemotherapy treatments more effective.Pathological grading and staging of pelvic lymph node-negative muscle invasive bladder cancer were independent risk factors should receive adequate attention,thereby improving prognosis of pelvic lymph node-negative muscle invasive bladder cancer. Key words: Urinary Bladder Neoplasms; Cystectomy; Lymph Nodes ; Prognosis