Analysis on composition and antibiotic resistance of pathogenic bacteria in surgical infection

Abstract

Objective To study the etiology of surgical infection and antibiotic resistance of infective bacteria,so as to provide evidence for clinical treatment.Method The composition and antibiotic resistance in surgical specimens of pathogenic bacteria from January 2008 to December 2010 was analyzed retrospectively.Results A total of 321 pathogens isolated,Gram-negative bacteria 201,accounting for 62.6％,Gram-positive cocci 114,accounting for 35.5％,Fungus 6,accounting for 1.9％.Escherichia coli 116(36.1％),Klebsiella pneumoniae 24(7.5％),Staphylococcus aureus 34(10.6％),Pseudomonas aeruginosa 18(5.6％),Enterococcus faecalis 16(5.0％).Staphylococcus species of Staphylococci methicillinresistant Staphylococcus atureus(MRS),Coagulase-negative staphylococci MRS and ultra wide-spectrum beta-lactamases(ESBLs)detection rate was 52.9％(18/34),83.7％(36/43)and 35.0％(49/140),respectively.The resistance rates of Gram-negative bacilli to piperacillin/tazobactam,ceftazidime,amikacin,imipenem and meropenem were below 20％,Gram-positive cocci,staphylococci to new compound sulfamethoxazole,minocycline,rifampin,vancomycin,teicoplanin and fusidic acid resistance rates were less than 40％,various pathogens had varies resistance.Conclusions Specimens of surgical infection pathogens widely distribute in different drug-resistant bacteria,some strains of multi-drug resistant infection,causing clinical failure of empirical therapy,clinical laboratory susceptibility results should be based on the rational use of antibiotics,to avoid the overuse of antibiotics. Key words: Surgical wound infection;  Noxae;  Drug tolerance