Abstract
The DIET (ordualintervalechotrain) sequence, a modification of thefastspinecho (FSE) sequence that selectively reduces signal from fat in MR images, has been investigated. The DIET sequence uses an initial echo spacing longer than that of a conventional FSE sequence, thus allowingJcoupling-induced dephasing to take effect. The sequence is evaluated theoretically, and its effectiveness on a hydrocarbon (1-pentene) is demonstrated numerically using density matrix calculations. The sequence is also evaluated experimentally usingin vitrosolutions andin vivoimaging. The efficacy of the sequence is compared for different lipid chemical structures, field strengths, and pulse sequence parameters.
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