Abstract
Objective:To investigate the differences of virulence genes of Staphylococcus aureus in patients with chronic sinusitis with nasal polyps (CRSwNP) and chronic sinusitis without nasal polyps (CRSsNP), and to explore the relationship between different virulence factors and the incidence of sinusitis and nasal polyps.Method:The PCR method was used to detect 17 kinds of virulence genes of Staphylococcus aureus isolated from nasal secretions of 41 strains.Result:①The detection rate of SEB in the experimental group was significantly higher than that in the control group, the detection rate of SEB in the CRSwNP group was higher than that in the CRSsNP group, and the other 5 kinds of enterotoxin genes were not statistically significant between the experimental group and the control group;②Staphylococcus aureus adhesin in the experimental group and the control group were detected, and the detection rate was relative higher in both control and experimental goups. However, the detection rate were not statistically significant between the experimental group and the control group;③The detection rate of HLα and HLβ genes encoding hemolysin was higher in the experimental group and the control group, and there was no significant difference between the 2 groups in the experimental group and the control group.Conclusion:Staphylococcus aureus carrying enterotoxin gene was more likely to cause CRS. The greater the incidence of nasal polyps was found in patients infected by Staphylococcus aureus carrying more enterotoxin gene.
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