Abstract
Introduction Lymph node metastasis is associated with poor prognosis in oral squamous cell carcinoma. So, it’s important to identify most influencing histological parameter in association with lymph node metastasis. Aim Of Study: The aim of this study is to analyze various histological parameter including tumor buds and worst pattern of invasion to check its association with lymph node metastasis positive cases. Materials & Methods The study done on 100 oral squamous cell carcinoma patients. The various histopathological parameters like Nuclear Pleomorphism, Number of mitosis, Lymphoplasmacytic inflammation along with tumor buds and WPOI analyzed to check association with node metastasis. The data was tabulated and Fischer’s exact & chi square test applied to calculate p value. Result Invasive tumor buds more than 5 and worst pattern of invasion (WPOI) were strongly associated with positive lymph node metastasis cases. The p value for both has been lowest among all other parameter. Conclusion The tumor buds and Pattern of invasion are most important emerging influencing factor having strong association with nodal metastasis and thus high risk patient can be identified in biopsy specimen.
Highlights
Lymph node metastasis is associated with poor prognosis in oral squamous cell carcinoma
It has been reported that 20-40% cases of oral squamous cell carcinoma have occult metastasis during presentation to hospital.1,2The chances of long term survival increased up to 40-50% after surgery in lymph node metastasis free patient as compare to lymph node metastasis positive cases.3The prognostic survival is high in node metastasis negative case with treatment as compare to node metastasis positive cases
The aim of this study is to analyze various histological parameter including tumor buds and worst pattern of invasion to check its association with lymph node metastasis positive cases
Summary
Lymph node metastasis is associated with poor prognosis in oral squamous cell carcinoma. Aim of Study: The aim of this study is to analyze various histological parameter including tumor buds and worst pattern of invasion to check its association with lymph node metastasis positive cases. Conclusion: The tumor buds and Pattern of invasion are most important emerging influencing factor having strong association with nodal metastasis and high risk patient can be identified in biopsy specimen. Lymph node involvement is very important prognosticator in oral Squamous cell carcinoma cases.[4,5,6,7] So, it’s important to identify most influencing histological parameter in association with lymph node metastasis. The aim of this study is to analyze various histological parameter including tumor buds and worst pattern of invasion to check its association with lymph node metastasis positive cases
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