Abstract
Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (<65 years) with the TRIM21 rs915956 A allele had a probability of HCC (AOR = 3.153, 95% CI: 1.315–7.516, p = 0.010). Moreover, patients with a smoking habit who carried the T allele of rs4144331 had more probability of HCC (AOR = 2.940, 95% CI: 1.331–6.491, p = 0.008). In addition, we observed that the polymorphic T allele of rs4144331 led to distant metastasis. Thus, our findings suggest that genetic variations in TRIM21 may correlate to HCC and evaluate distant metastasis in patients with HCC.
Highlights
Owing to endemic hepatitis B and C virus infections, hepatocellular carcinoma (HCC)happens commonly among Asian and African populations [1]
A total of 1196 healthy controls and 394 patients with HCC were recruited for this case–cohort study
The results have suggested that Tripartite motif 21 (TRIM21) acts as a tumor suppresser and is correlated with malignant potential and poor prognosis in HCC [4]
Summary
Owing to endemic hepatitis B and C virus infections, hepatocellular carcinoma (HCC)happens commonly among Asian and African populations [1]. Owing to endemic hepatitis B and C virus infections, hepatocellular carcinoma (HCC). HCC is one of the deadliest and most prevalent cancers worldwide. HCC develops when mutations in the cellular machinery cause the cells to replicate at a higher rate or cause the cells to avoid undergoing apoptosis. Chronic hepatitis B or C virus infection can cause the immune system to attack liver cells repeatedly, which contributes to the development of HCC [2]. A recent report demonstrated that the RING domain of TRIM21 can promote HBV DNA polymerase degradation. Lys283 and Lys260 of HBV DNA Pol were identified as targets for ubiquitination mediated by TRIM21 [3]. TRIM21 silencing has been demonstrated to promote
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