Abstract
A transdermal patch is a method of drug delivery through the skin into the bloodstream that is composed of layers that store and release the active pharmaceutical ingredient (API) over time. The ability to analyze these layers without damaging the patch allows for quality control and stability measurements. Raman spectroscopy has excellent chemical identification abilities, thanks to the fingerprint like spectrum it produces, that deliver rapid discrimination between components typically found in transdermal patches, such as polymers and APIs. Coupling this with a confocal microscope gives high spatial resolution on all three axes, with the pinhole providing otherwise unachievable axial resolution, permitting depth profile analysis. Using this technique, the patch can be analyzed from top to bottom without any risk of damage. This article highlights the use of confocal Raman microscopy to acquire a 3D Raman map of a transdermal patch for layer evaluation. The map revealed six layers which were composed of four polymers and the API layer at the center of the patch.
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