Abstract
The purulent-septic infection caused by Staphylococcus aureus is one of the biggest problems of modern medicine. There are some strategies to control the increasing antibiotic resistance of bacteria. They are the development and introduction of new antibacterial drugs into surgical practice, the improvement of antimicrobial therapy methods and the rotation of antibacterial drugs [1, 2, 3]. Staphylococcus aureus is one of the most common causative agents of infections of various localizations. The development of mechanisms of antibiotic resistance of bacteria is more often determined by genes located on the bacterial chromosome or Rplasmids. Particular attention is paid to methicillinresistant staphylococci (MRS strains). They are registered in nosocomial or out-of-hospital infections. The resistance of staphylococci to β-lactam antibiotics is due to the presence of the mec A gene. It encodes the penicillin-binding protein (PBP). The mec A gene is located on a mobile genetic element. This element is called the staphylococcal chromosome cassette (SCCmec). Methicillin-resistant Staphylococcus aureus is resistant to all β-lactam antibiotics. Currently, it is necessary to use combinations of antibacterial drugs for the treatment of infections caused by methicillinresistant staphylococci.
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