Abstract
✓ An analysis of 12 consecutive cases of brain abscess is reported. In nine patients a distant focus of infection was identified in the middle ear, the cranial sinuses, the lungs, the pleura, the tonsils, or the skull. The most frequent early symptoms and signs were headache, vomiting, papilledema, focal neurological abnormalities, and pyrexia. Angiography, electroencephalography, and brain scans were abnormal in all cases in which they were obtained. Therapy was based on early diagnosis with accurate location, aspiration or excision of the abscess, use of chloramphenicol instead of penicillin, use of steroids, the accomplishment of simultaneous treatment of the primary source of infection, and reevaluation of the patient some time after discharge. The mortality rate was 8% and the morbidity 8%; the six patients with postoperative epilepsy have returned to normal life.
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