Abstract
Background The earliest histological signs of autoimmunity in female NOD mice occur at approximately 4 weeks of age. We hypothesized that defects associated with these events may be evident in the molecular signatures of spleen leukocytes. To gain a detailed insight into these early molecular defects we analyzed the transcriptomes of CD4 Tlymphocytes, the predominant leukocyte subset involved in autoimmune diabetes.
Highlights
Open AccessAddress: 1Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38104, USA and 2Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, USA
The earliest histological signs of autoimmunity in female Non-Obese Diabetic (NOD) mice occur at approximately 4 weeks of age
UT-ORNL-KBRIN Bioinformatics Summit 2008 Eric C Rouchka and Julia Krushkal Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.kbrin.louisville.edu/summit/
Summary
Address: 1Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38104, USA and 2Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, USA. UT-ORNL-KBRIN Bioinformatics Summit 2008 Eric C Rouchka and Julia Krushkal Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.kbrin.louisville.edu/summit/
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