Analysis of the Total Level of Flavonoids in the Brown Algae ( Phaeophyceae ) Extract as Analgesic and Anti-Inflammatory Drugs

Andi Tajrin,Surijana Mappangara,Fuad Husain Akbar,Rasmidar Samad,Muhammad Ruslin,Muh Hendra Chandha

doi:10.1590/pboci.2020.103

Andi Tajrin, Surijana Mappangara + Show 4 more

Open Access

https://doi.org/10.1590/pboci.2020.103

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Abstract

Objective: To determine the total level of flavonoids in brown algae extract Padina sp ., Sargassum sp ., and Turbinaria sp ., which could serve as an analgesic and anti-inflammatory drug. Material and Methods: This is an experimental study with a one-shot case study research design. The study sample consisted of three species of brown algae, namely, Padina sp ., Sargassum sp ., and Turbinaria sp . The study samples were obtained from Saugi Island, Pangkep, Regency. The sampling method used was convenience sampling. The total flavonoid level in the three extracts of brown algae samples was determined at three concentrations (150 ppm, 300 ppm, and 450 ppm) with three replicates. The analysis used a colorimetric method, a spectrophotometer and aluminium chloride as the reagent . Results: The total level of flavonoids in Padina sp . was the highest at 0.894 ± 0.027%, compared to the levels of 0.786 ± 0.075% in Sargassum sp . and 0.745 ± 0.016% in Turbinaria sp . Conclusion: Padina sp . had the highest total flavonoid levels compared to Sargassum sp . and Turbinaria sp . Flavonoid compounds from brown algae have the potential to be used as analgesic and anti-inflammatory drugs.

Highlights

Various oral treatments, such as extraction or surgical procedures, can result in complications in the form of wounds that cause pain accompanied by inflammation
The study sample consisted of three species of brown algae, namely, Padina sp., Sargassum sp., and Turbinaria sp
Padina sp. had the highest total flavonoid levels compared to Sargassum sp. and Turbinaria sp

Summary

Introduction

Various oral treatments, such as extraction or surgical procedures, can result in complications in the form of wounds that cause pain accompanied by inflammation. The most common approach to reducing pain is the administration of analgesic drugs. Analgesic drugs usually have the effects of being antipyretic and anti-inflammatory. It is estimated that among users of long-term analgesic and anti-inflammatory drugs: 15–40% will have upper gastrointestinal complaints; 10–25% will suffer from peptic ulcers, especially gastric ulcers; and 1–4% will have ulcer complications that can be life-threatening, such as bleeding and perforation. To reduce the side effects from these drugs, it is necessary to find alternative analgesics and anti-inflammatory medicines with natural ingredients, mainly from plants [3]

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